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  • Evidence is increasing that most addiction without exception is related to problems with the brain's reward center, specially the mesolimbic system. This part of the problem regulates reward responses in getting food and sex, plus nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both whenever they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the amount of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).

    Using two separate drugs to shed weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight reduction and the those who go through it one should err to the side of caution and allow FDA do its job and demand some research be done so your public is aware of the side effects and perils associated with the medications before we take them. Keep in mind that drug companies have been in business to generate money and that they would say everything to keep people on their own medications.

    Researchers discovered that participants using this drug for a year, dropped a few pounds within four weeks and have kept the weight off during the entire 56 weeks in the study. Contrave is often a combination from the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs which might be made up of many active ingredient, which can make them more effective and safer.

    Combo-pilling may be the newest fad or even better the newest ahead under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills is now popular is the fact that at the time of right now there aren't any long term prescription weight loss supplements that have been approved by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be approved by the FDA.

    Seizures can be a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug also can raise blood pressure level and heart rate, and shouldn't be used in individuals with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

    The FDA also warned that Contrave can raise blood pressure level and heart rate and must not used in patients with uncontrolled high blood pressure level, and also by anyone with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients using a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients for the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking.

    The most common unwanted side effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.